Microalbuminuria in Obese Children and Adolescents and the Metabolic Syndrome

  • Heba ElSedfy
  • Nadin Toaima Ain Shams University
  • Mayada Ahmad
  • Lerine Bahy El Din

Abstract

Insulin resistance is a common feature of childhood obesity and is considered to be an important link between adiposity and development of type 2 diabetes mellitus and cardiovascular disease. It is also a major contributing factor to renal injury. Microalbuminuria (albumin excretion 20-200 mg∕min or 30-300 mg∕gram creatinine) is now considered an early marker of renal damage in non-diabetic patients.


 Objectives: to evaluate the association of obesity and microalbuminuria among obese subjects and its relation to metabolic syndrome components.


Methods: This cross-sectional study was conducted on sixty two obese children and adolescents randomly recruited from the Obesity Clinic, Pediatric Hospital, Ain-Shams University. Anthropometric data were collected, fasting serum insulin, glucose and serum  lipid profile were measured. The homeostasis model assessment of insulin resistance (HOMA-IR) was used to calculate in vivo insulin resistance. Oral glucose tolerance test and urinary albumin concentrations were done. 


Results: Microalbuminuria was detected  in  18 cases (29%) , metabolic syndrome in 4 cases (6.4%), impaired OGTT  in 9.6%. Impaired fasting insulin and high serum insulin after 2 hours in OGTT in 3.2% of cases. Abnormal lipid profile was significantly associated with  microalbuminuria.


Conclusion: Microalbuminuria is strongly associated with impaired fasting insulin, and abnormal lipid profile.


 

Published
Oct 3, 2017
How to Cite
ELSEDFY, Heba et al. Microalbuminuria in Obese Children and Adolescents and the Metabolic Syndrome. International Annals of Medicine, [S.l.], v. 1, n. 10, oct. 2017. ISSN 2520-5110. Available at: <https://iamresearcher.online/ojs/index.php/iam/article/view/301>. Date accessed: 21 oct. 2017. doi: https://doi.org/10.24087/IAM.2017.1.10.301.
Section
Original Research